RapamycinFungusV1, Main, Exploration, bibRecord, 000B61

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

Identifieur interne : 000B61 ( Main/Exploration ); précédent : 000B60; suivant : 000B62

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

Auteurs : Michael A. Kennedy ; Tia C. Moffat ; Kenneth Gable [États-Unis] ; Suriakarthiga Ganesan [Canada] ; Karolina Niewola-Staszkowska [Suisse] ; Anne Johnston [Canada] ; Corey Nislow [Canada] ; Guri Giaever [Canada] ; Linda J. Harris [Canada] ; Robbie Loewith [Suisse] ; Vanina Zaremberg [Canada] ; Mary-Ellen Harper ; Teresa Dunn [États-Unis] ; Steffany A L. Bennett ; Kristin Baetz

Source :

Scientific reports [ 2045-2322 ] ; 2016.

RBID : pubmed:26757638

Descripteurs français

English descriptors

KwdEn :
- Alzheimer Disease (genetics), Alzheimer Disease (metabolism), Alzheimer Disease (pathology), Amyloid beta-Peptides (metabolism), Cell Line (MeSH), Cells, Cultured (MeSH), Ceramides (metabolism), Gene Expression Profiling (MeSH), Humans (MeSH), Lipid Metabolism (genetics), Mechanistic Target of Rapamycin Complex 2 (MeSH), Membrane Potential, Mitochondrial (MeSH), Mitochondria (genetics), Mitochondria (metabolism), Multiprotein Complexes (metabolism), Neurons (metabolism), Open Reading Frames (MeSH), Oxidative Stress (MeSH), Reactive Oxygen Species (metabolism), Signal Transduction (MeSH), TOR Serine-Threonine Kinases (metabolism).
MESH :
- chemical , metabolism : Amyloid beta-Peptides, Ceramides, Multiprotein Complexes, Reactive Oxygen Species, TOR Serine-Threonine Kinases.
- genetics : Alzheimer Disease, Lipid Metabolism, Mitochondria.
- metabolism : Alzheimer Disease, Mitochondria, Neurons.
- pathology : Alzheimer Disease.
- Cell Line, Cells, Cultured, Gene Expression Profiling, Humans, Mechanistic Target of Rapamycin Complex 2, Membrane Potential, Mitochondrial, Open Reading Frames, Oxidative Stress, Signal Transduction.

Abstract

Fundamental changes in the composition and distribution of lipids within the brain are believed to contribute to the cognitive decline associated with Alzheimer's disease (AD). The mechanisms by which these changes in lipid composition affect cellular function and ultimately cognition are not well understood. Although "candidate gene" approaches can provide insight into the effects of dysregulated lipid metabolism they require a preexisting understanding of the molecular targets of individual lipid species. In this report we combine unbiased gene expression profiling with a genome-wide chemogenomic screen to identify the mitochondria as an important downstream target of PC(O-16:0/2:0), a neurotoxic lipid species elevated in AD. Further examination revealed that PC(O-16:0/2:0) similarly promotes a global increase in ceramide accumulation in human neurons which was associated with mitochondrial-derived reactive oxygen species (ROS) and toxicity. These findings suggest that PC(O-16:0/2:0)-dependent mitochondrial dysfunction may be an underlying contributing factor to the ROS production associated with AD.

DOI: 10.1038/srep19332
PubMed: 26757638
PubMed Central: PMC4725818

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000B23
to stream Main, to step Curation: 000B23

Le document en format XML

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<wicri:noCountry code="subField">KlH 8M5 Canada</wicri:noCountry>
</affiliation>
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<author><name sortKey="Baetz, Kristin" sort="Baetz, Kristin" uniqKey="Baetz K" first="Kristin" last="Baetz">Kristin Baetz</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.</title>
<author><name sortKey="Kennedy, Michael A" sort="Kennedy, Michael A" uniqKey="Kennedy M" first="Michael A" last="Kennedy">Michael A. Kennedy</name>
<affiliation><nlm:affiliation>Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, KlH 8M5 Canada.</nlm:affiliation>
<wicri:noCountry code="subField">KlH 8M5 Canada</wicri:noCountry>
</affiliation>
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<author><name sortKey="Moffat, Tia C" sort="Moffat, Tia C" uniqKey="Moffat T" first="Tia C" last="Moffat">Tia C. Moffat</name>
<affiliation><nlm:affiliation>Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, KlH 8M5 Canada.</nlm:affiliation>
<wicri:noCountry code="subField">KlH 8M5 Canada</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gable, Kenneth" sort="Gable, Kenneth" uniqKey="Gable K" first="Kenneth" last="Gable">Kenneth Gable</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20184-4799, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<orgName type="university">Université de Calgary</orgName>
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<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
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<author><name sortKey="Niewola Staszkowska, Karolina" sort="Niewola Staszkowska, Karolina" uniqKey="Niewola Staszkowska K" first="Karolina" last="Niewola-Staszkowska">Karolina Niewola-Staszkowska</name>
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<country xml:lang="fr">Suisse</country>
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<country xml:lang="fr">Canada</country>
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<author><name sortKey="Nislow, Corey" sort="Nislow, Corey" uniqKey="Nislow C" first="Corey" last="Nislow">Corey Nislow</name>
<affiliation wicri:level="4"><nlm:affiliation>University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of British Columbia, Vancouver, British Columbia V6T 1Z3</wicri:regionArea>
<orgName type="university">Université de la Colombie-Britannique</orgName>
<placeName><settlement type="city">Vancouver</settlement>
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<author><name sortKey="Giaever, Guri" sort="Giaever, Guri" uniqKey="Giaever G" first="Guri" last="Giaever">Guri Giaever</name>
<affiliation wicri:level="4"><nlm:affiliation>University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of British Columbia, Vancouver, British Columbia V6T 1Z3</wicri:regionArea>
<orgName type="university">Université de la Colombie-Britannique</orgName>
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</placeName>
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<author><name sortKey="Harris, Linda J" sort="Harris, Linda J" uniqKey="Harris L" first="Linda J" last="Harris">Linda J. Harris</name>
<affiliation wicri:level="1"><nlm:affiliation>Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, Ontario K1A 0C6, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, Ontario K1A 0C6</wicri:regionArea>
<wicri:noRegion>Ontario K1A 0C6</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Loewith, Robbie" sort="Loewith, Robbie" uniqKey="Loewith R" first="Robbie" last="Loewith">Robbie Loewith</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Biology and Swiss National Center for Competence in Research Programme Chemical Biology, University of Geneva, Geneva 1211, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Molecular Biology and Swiss National Center for Competence in Research Programme Chemical Biology, University of Geneva, Geneva 1211</wicri:regionArea>
<orgName type="university">Université de Genève</orgName>
<placeName><settlement type="city">Genève</settlement>
<region nuts="3" type="region">Canton de Genève</region>
</placeName>
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<author><name sortKey="Zaremberg, Vanina" sort="Zaremberg, Vanina" uniqKey="Zaremberg V" first="Vanina" last="Zaremberg">Vanina Zaremberg</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biological Sciences, University of Calgary, AB, T2N 1N4 Canada.</nlm:affiliation>
<orgName type="university">Université de Calgary</orgName>
<country>Canada</country>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
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<author><name sortKey="Harper, Mary Ellen" sort="Harper, Mary Ellen" uniqKey="Harper M" first="Mary-Ellen" last="Harper">Mary-Ellen Harper</name>
<affiliation><nlm:affiliation>Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, KlH 8M5 Canada.</nlm:affiliation>
<wicri:noCountry code="subField">KlH 8M5 Canada</wicri:noCountry>
</affiliation>
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<author><name sortKey="Dunn, Teresa" sort="Dunn, Teresa" uniqKey="Dunn T" first="Teresa" last="Dunn">Teresa Dunn</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20184-4799, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20184-4799</wicri:regionArea>
<wicri:noRegion>Maryland 20184-4799</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bennett, Steffany A L" sort="Bennett, Steffany A L" uniqKey="Bennett S" first="Steffany A L" last="Bennett">Steffany A L. Bennett</name>
<affiliation><nlm:affiliation>Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, KlH 8M5 Canada.</nlm:affiliation>
<wicri:noCountry code="subField">KlH 8M5 Canada</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Baetz, Kristin" sort="Baetz, Kristin" uniqKey="Baetz K" first="Kristin" last="Baetz">Kristin Baetz</name>
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<wicri:noCountry code="subField">KlH 8M5 Canada</wicri:noCountry>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (genetics)</term>
<term>Alzheimer Disease (metabolism)</term>
<term>Alzheimer Disease (pathology)</term>
<term>Amyloid beta-Peptides (metabolism)</term>
<term>Cell Line (MeSH)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Ceramides (metabolism)</term>
<term>Gene Expression Profiling (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Lipid Metabolism (genetics)</term>
<term>Mechanistic Target of Rapamycin Complex 2 (MeSH)</term>
<term>Membrane Potential, Mitochondrial (MeSH)</term>
<term>Mitochondria (genetics)</term>
<term>Mitochondria (metabolism)</term>
<term>Multiprotein Complexes (metabolism)</term>
<term>Neurons (metabolism)</term>
<term>Open Reading Frames (MeSH)</term>
<term>Oxidative Stress (MeSH)</term>
<term>Reactive Oxygen Species (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes (MeSH)</term>
<term>Cadres ouverts de lecture (MeSH)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Complexe-2 cible mécanistique de la rapamycine (MeSH)</term>
<term>Complexes multiprotéiques (métabolisme)</term>
<term>Céramides (métabolisme)</term>
<term>Espèces réactives de l'oxygène (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Maladie d'Alzheimer (anatomopathologie)</term>
<term>Maladie d'Alzheimer (génétique)</term>
<term>Maladie d'Alzheimer (métabolisme)</term>
<term>Mitochondries (génétique)</term>
<term>Mitochondries (métabolisme)</term>
<term>Métabolisme lipidique (génétique)</term>
<term>Neurones (métabolisme)</term>
<term>Peptides bêta-amyloïdes (métabolisme)</term>
<term>Potentiel de membrane mitochondriale (MeSH)</term>
<term>Stress oxydatif (MeSH)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amyloid beta-Peptides</term>
<term>Ceramides</term>
<term>Multiprotein Complexes</term>
<term>Reactive Oxygen Species</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladie d'Alzheimer</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term>
<term>Lipid Metabolism</term>
<term>Mitochondria</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Maladie d'Alzheimer</term>
<term>Mitochondries</term>
<term>Métabolisme lipidique</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term>
<term>Mitochondria</term>
<term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complexes multiprotéiques</term>
<term>Céramides</term>
<term>Espèces réactives de l'oxygène</term>
<term>Maladie d'Alzheimer</term>
<term>Mitochondries</term>
<term>Neurones</term>
<term>Peptides bêta-amyloïdes</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alzheimer Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cell Line</term>
<term>Cells, Cultured</term>
<term>Gene Expression Profiling</term>
<term>Humans</term>
<term>Mechanistic Target of Rapamycin Complex 2</term>
<term>Membrane Potential, Mitochondrial</term>
<term>Open Reading Frames</term>
<term>Oxidative Stress</term>
<term>Signal Transduction</term>
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<term>Cadres ouverts de lecture</term>
<term>Cellules cultivées</term>
<term>Complexe-2 cible mécanistique de la rapamycine</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Potentiel de membrane mitochondriale</term>
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<front><div type="abstract" xml:lang="en">Fundamental changes in the composition and distribution of lipids within the brain are believed to contribute to the cognitive decline associated with Alzheimer's disease (AD). The mechanisms by which these changes in lipid composition affect cellular function and ultimately cognition are not well understood. Although "candidate gene" approaches can provide insight into the effects of dysregulated lipid metabolism they require a preexisting understanding of the molecular targets of individual lipid species. In this report we combine unbiased gene expression profiling with a genome-wide chemogenomic screen to identify the mitochondria as an important downstream target of PC(O-16:0/2:0), a neurotoxic lipid species elevated in AD. Further examination revealed that PC(O-16:0/2:0) similarly promotes a global increase in ceramide accumulation in human neurons which was associated with mitochondrial-derived reactive oxygen species (ROS) and toxicity. These findings suggest that PC(O-16:0/2:0)-dependent mitochondrial dysfunction may be an underlying contributing factor to the ROS production associated with AD. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26757638</PMID>
<DateCompleted><Year>2016</Year>
<Month>12</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>04</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>6</Volume>
<PubDate><Year>2016</Year>
<Month>Jan</Month>
<Day>13</Day>
</PubDate>
</JournalIssue>
<Title>Scientific reports</Title>
<ISOAbbreviation>Sci Rep</ISOAbbreviation>
</Journal>
<ArticleTitle>A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.</ArticleTitle>
<Pagination><MedlinePgn>19332</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/srep19332</ELocationID>
<Abstract><AbstractText>Fundamental changes in the composition and distribution of lipids within the brain are believed to contribute to the cognitive decline associated with Alzheimer's disease (AD). The mechanisms by which these changes in lipid composition affect cellular function and ultimately cognition are not well understood. Although "candidate gene" approaches can provide insight into the effects of dysregulated lipid metabolism they require a preexisting understanding of the molecular targets of individual lipid species. In this report we combine unbiased gene expression profiling with a genome-wide chemogenomic screen to identify the mitochondria as an important downstream target of PC(O-16:0/2:0), a neurotoxic lipid species elevated in AD. Further examination revealed that PC(O-16:0/2:0) similarly promotes a global increase in ceramide accumulation in human neurons which was associated with mitochondrial-derived reactive oxygen species (ROS) and toxicity. These findings suggest that PC(O-16:0/2:0)-dependent mitochondrial dysfunction may be an underlying contributing factor to the ROS production associated with AD. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kennedy</LastName>
<ForeName>Michael A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, KlH 8M5 Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moffat</LastName>
<ForeName>Tia C</ForeName>
<Initials>TC</Initials>
<AffiliationInfo><Affiliation>Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, KlH 8M5 Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gable</LastName>
<ForeName>Kenneth</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20184-4799, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ganesan</LastName>
<ForeName>Suriakarthiga</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Biological Sciences, University of Calgary, AB, T2N 1N4 Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Niewola-Staszkowska</LastName>
<ForeName>Karolina</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology and Swiss National Center for Competence in Research Programme Chemical Biology, University of Geneva, Geneva 1211, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Johnston</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, Ontario K1A 0C6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nislow</LastName>
<ForeName>Corey</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Giaever</LastName>
<ForeName>Guri</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Harris</LastName>
<ForeName>Linda J</ForeName>
<Initials>LJ</Initials>
<AffiliationInfo><Affiliation>Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, Ontario K1A 0C6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Loewith</LastName>
<ForeName>Robbie</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology and Swiss National Center for Competence in Research Programme Chemical Biology, University of Geneva, Geneva 1211, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zaremberg</LastName>
<ForeName>Vanina</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Department of Biological Sciences, University of Calgary, AB, T2N 1N4 Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Harper</LastName>
<ForeName>Mary-Ellen</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, KlH 8M5 Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dunn</LastName>
<ForeName>Teresa</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20184-4799, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bennett</LastName>
<ForeName>Steffany A L</ForeName>
<Initials>SAL</Initials>
<AffiliationInfo><Affiliation>Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, KlH 8M5 Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baetz</LastName>
<ForeName>Kristin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, KlH 8M5 Canada.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>MOP 311838</GrantID>
<Agency>Canadian Institutes of Health Research</Agency>
<Country>Canada</Country>
</Grant>
<Grant><GrantID>MOP 57810</GrantID>
<Agency>Canadian Institutes of Health Research</Agency>
<Country>Canada</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>01</Month>
<Day>13</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Sci Rep</MedlineTA>
<NlmUniqueID>101563288</NlmUniqueID>
<ISSNLinking>2045-2322</ISSNLinking>
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</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
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<Chemical><RegistryNumber>0</RegistryNumber>
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<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016366" MajorTopicYN="N">Open Reading Frames</DescriptorName>
</MeshHeading>
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<MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="Y">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
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<country name="Canada"><region name="Alberta"><name sortKey="Ganesan, Suriakarthiga" sort="Ganesan, Suriakarthiga" uniqKey="Ganesan S" first="Suriakarthiga" last="Ganesan">Suriakarthiga Ganesan</name>
</region>
<name sortKey="Giaever, Guri" sort="Giaever, Guri" uniqKey="Giaever G" first="Guri" last="Giaever">Guri Giaever</name>
<name sortKey="Harris, Linda J" sort="Harris, Linda J" uniqKey="Harris L" first="Linda J" last="Harris">Linda J. Harris</name>
<name sortKey="Johnston, Anne" sort="Johnston, Anne" uniqKey="Johnston A" first="Anne" last="Johnston">Anne Johnston</name>
<name sortKey="Nislow, Corey" sort="Nislow, Corey" uniqKey="Nislow C" first="Corey" last="Nislow">Corey Nislow</name>
<name sortKey="Zaremberg, Vanina" sort="Zaremberg, Vanina" uniqKey="Zaremberg V" first="Vanina" last="Zaremberg">Vanina Zaremberg</name>
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<country name="Suisse"><region name="Canton de Genève"><name sortKey="Niewola Staszkowska, Karolina" sort="Niewola Staszkowska, Karolina" uniqKey="Niewola Staszkowska K" first="Karolina" last="Niewola-Staszkowska">Karolina Niewola-Staszkowska</name>
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<name sortKey="Loewith, Robbie" sort="Loewith, Robbie" uniqKey="Loewith R" first="Robbie" last="Loewith">Robbie Loewith</name>
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</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B61 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B61 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:26757638
   |texte=   A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26757638" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki